Ting-Han Chang

Affiliations

1. Institute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan
2. Department of Dentistry, College of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan

Discipline

Oral and Maxillofacial surgery

Faculty Appointments (in chronological order)

02/24 -             Assistant Professor, Institute of Oral Biology, School of Dentistry, National Yang-Ming University. Taipei, Taiwan

02/21- 01/24    Assistant Professor, Department of Dentistry, School of Dentistry, National Yang-Ming University. Taipei, Taiwan

Education (in chronological order)

07/16-05/20     DScD, Dental Medicine, University of Pennsylvania, USA

09/02-06/08     DDS, Chung Shan Medical University, Taiwan

Fellowship Appointment (in chronological order)

2022 -       Fellow of the Higher Education Academy (FHEA)

2017 -       Member of International Association for Dental Research/American Association for Dental Research

2014 -       Member of Taiwan Academy of Facial Plastic and Reconstructive Surgery

2012 -       Member of ITI International Team for Implantology

2008 -       Member of Association of Oral and Maxillofacial Surgery, Taiwan

2008 -       Member of Dental Science Association, Taiwan

Tel: (+886)-2-2826-7118

Fax: (+886)-2-2826-4053

E-mail: cth0616@nycu.edu.tw

Fields of Specialty:

Odontogenic Tumor, Stem Cell Biology, Organoid, Animal Model

Research Description:

My research focuses on odontogenic tumors, particularly ameloblastoma—a locally aggressive benign tumor. Our previous work identified LGR5⁺ ameloblastoma epithelial stem-like cells as contributors to resistance against BRAFV600E-targeted therapies. To further investigate the tumor microenvironment, we performed single-cell ATAC-seq and RNA-seq analyses, aiming to identify specific molecular targets. In addition, we have established ameloblastoma organoids and orthotopic mouse models to study molecular mechanisms in depth and to conduct preclinical drug testing. Our ultimate goal is to develop a drug screening platform and identify novel therapies for clinical trials, with the aim of advancing personalized precision treatment for patients.

Research Projects/Grants:

1. Tumor microenvironment regulation of LGR5 stem-like cells in Ameloblastoma/ NSTC 110-2314-B-A49A-553-MY3
2. Investigation and Target Exosomal MicroRNAs in Ameloblastoma Microenvironment/ NSTC 113-2314-B-A49-021
3. Investigation the Molecular Mechanism of Ameloblastoma by Targeting Activin A - New Preclinical Orthotopic Animal Model and Translational Medicine Research/ NSTC 114-2314-B-A49-035

Key Publications:

1. Ting-Han Chang, Rabie M. Shanti, Yanfang Liang, Jincheng Zeng, Shihong Shi, Faizan Alawi, Lee Carrasco, Qunzhou Zhang, and Anh D. Le (2020, May). LGR5+ epithelial tumor stem-like cells generate a 3D-organoid model for ameloblastoma. Cell Death & Disease. (IF: 8.469), 11(5):338. (SCI, 37/195, Cell Biology).  
2. Chunmiao Jiang, Qunzhou Zhang, Rabie M. Shanti, Shihong Shi, Ting-Han Chang, Lee Carrasco, Faizan Alawi, Anh D. Le. (2017, Sep). Mesenchymal Stromal Cell-derived IL-6 Promotes Epithelial-mesenchymal Transition and Acquisition of Epithelial Stem-like Cell Properties in Ameloblastoma Epithelial Cells. Stem Cells. (IF: 6.277), 5(9):2083-2094. (SCI, 58/195, CELL BIOLOGY).
3. Qilin Xu, Akihiro Furuhashi, Qunzhou Zhang, Chunmiao Jiang, Ting-Han Chang, and Anh D. Le. (2017, Aug). Induction of Salivary Gland–Like Cells from Dental Follicle Epithelial Cells. Journal of Dental Research. (IF: 6.116), 96(9):1035-1043. (SCI, 2/150, DENTISTRY, ORAL SURGERY & MEDICINE).
4. Ting-Han Chang, Da-Yo Yuh, Yung-Tsan Wu, Wan-Chien Cheng, Fu-Gong Lin, Yi-Shing Shieh, Earl Fu, Ren-Yeong Huang (2015, Nov). The association between temporomandibular disorders and joint hypermobility syndrome: a nationwide population-based study. Clinical Oral Investigations, 19(8):2123-32. (SCI, 21/91, DENTISTRY, ORAL SURGERY & MEDICINE).
5. Da-Yo Yuh, Ting-Han Chang, Ren-Yeong Huang, Wu-Chien Chien, Fu-Gong Lin, Earl Fu. (2014, Oct). The National-Scale Cohort Study on Bisphosphonate-Related Osteonecrosis of the Jaw in Taiwan. Journal of Dentistry, 42(10):1343-52. (SCI, 8/150, DENTISTRY, ORAL SURGERY & MEDICINE).