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Professor Wan-Chun Li-Image
Professor

Wan-Chun Li

Oral Biology

Affiliations

  1. Institute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan
  2. Department of Dentistry, College of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan
  3. Oral Medicine Innovation Center (OMIC), National Yang Ming Chiao Tung University, Taipei, Taiwan
  4. Department of Stomatology, Taipei Veterans General Hospital, Taipei, Taiwan

 

Faculty Appointments (in chronological order)

01/24 -             Contract Research Fellow, Department of Stomatology, Taipei Veterans General Hospital, Taipei, Taiwan

08/23 -      Distinguished Professor, Institute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University. Taipei, Taiwan

02/21 - 07/23   Professor, Institute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University. Taipei, Taiwan

02/17 - 01/21   Associate Professor, Institute of Oral Biology, School of Dentistry, National Yang-Ming University. Taipei, Taiwan

08/14 - 01/17   Assistant Professor, Institute of Oral Biology, School of Dentistry, National Yang-Ming University. Taipei, Taiwan

08/11- 07/14    Assistant Professor, Department of Dentistry, School of Dentistry, National Yang-Ming University. Taipei, Taiwan

11/11- 07/14    Jointed Assistant Research Fellow, Taipei City Hospital, Taipei, Taiwan

 

Education (in chronological order)

10/02-05/06     Ph.D, Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of BATH, BATH, England, UK

09/00-06/02     M.Sc, School of Dentistry, Department of Oral Biology, National Yang-Ming University, Taipei, Taiwan.

09/97-06/00     B.Sc, School of Medical Technology, Chang Gung University, Tao-Yuan, Taiwan

 

Fellowship Appointment (in chronological order)

06/10 - 07/11   Postdoctoral Fellow, Lund Stem Cell Institute, BioＭedical Centre (BMC), Lunds University, Sweden

05/06 - 04/10   Postdoctoral Fellow, Section of Islet Transplantation & Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, USA

 

Administrative Appointments (in chronological order)

08/20 -             Director, Institute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University. Taipei, Taiwan

12/21 -             Member of the Board of Directors, Taiwan Society for Stem Cell Research (TSSCR), Taiwan

11/19 - 11/21   Secretary General, Taiwan Society for Stem Cell Research (TSSCR), Taiwan

08/19 - 07/20   Deputy Chairman, Department of Dentistry, School of Dentistry, National Yang-Ming University. Taipei, Taiwan

 

Tel: (+886)-2-2826-7255

Fax: (+886)-2-2826-4053

E-mail: wcli@nycu.edu.tw

 

Fields of Specialty:

Cell & Molecular Biology, Endocrinology (Diabetes), Stem Cell Biology, Oncology

 

Research Description/Projects:

Laboratory of Metabolic Oncology & Regenerative Medicine

Metabolic balance is essential in regulating physiological homeostasis. Considering great energy and biomass demand for cell growth, cancer cells exhibited unique metabolic signature compared to normal cells. The reversal of the cancerous metabolic cues had therefore been regarded as one of the therapeutic targets to develop anti-cancer schemes/drugs. Our laboratory has been focusing on investigating the roles of different metabolic cues in controlling head and neck cancer tumorigenesis. External and intrinsic metabolic regulations for head and neck carcinogenesis were emphasized. The ultimate goal of our research is to understand how cancer cells reprogram cellular metabolism to adapt environmental challenges in hope of establishing a useful platform for developing cancer metabolism based anti-cancer compounds or therapeutic strategies.

Numbers of projects in the laboratory were currently under investigation. They include: (1) To define intrinsic impacts of glucose/lipid/protein/mitochondrial metabolic regulations on carcinogenesis in various cancers including head and neck cancers, esophageal cancers, hepatocellular carcinoma and digestive track cancers; (2) To determine potential metabolic regulatory cue(s) in controlling treatment resistance and (3) To uncover dynamic metabolic changes in cells residing in tumor microenvironment.

 

Research Grants:

Grants funded by National Science and Technology Council (NSTC) in past 5 years:

2025/8-2026/7        Targeting Resistance Associated Metabolic and Molecular Cues to Facilitate Chemo/radio Therapeutic Sensitivity in Oral Cancers

(114-2314-B-A49-026-)

2024/8-2025/7        Multiomics Analysis for Metabolic Cues as Adjuvant Therapeutic Targets to Combat Treatment Resistance in Head and Neck Cancers

(113-2314-B-A49-017-)

2021/8-2024/7        Exploration of Treatment Resistant Related Metabolic Cues and its Potential for Development of a Pre-clinical model for Head and Neck Cancers

                               (110-2314-B-A49A-516 -MY3)

2020/8-2023/7         Multifaceted Roles of Mitochondrial Homeostasis in Head and Neck

Oncogenesis

                                (111-2628-B-A49 -008-/110-2628-B-A49A-511-/109-2628-B-010 -008-)

 

Key Publications:(*: corresponding author)

  1. Guerrero JJG, Encarnacion PC, del Rosario MAS, Ora MAS, Zhou J, Notarte KI, Li W-C*, Chang C-W* (2025). Genetic Variants Underlying Precancerous Conditions of Hepatocellular Carcinoma. International Journal of Cancer (Accepted)
  2. Huang P-C, Chang C-W, Lin Y-C, Chen C-Y, Chen T-Y, Chuang L-T, Liu C-J, Huang C-L, Li W-C* (2023). Pyruvate Kinase Differentially Alters Metabolic Signatures during Head and Neck Carcinogenesis. International Journal of Molecular Sciences, 24, 16639.
  3. Chien H-Y, Chen S-M, Li W-C* (2023). Dopamine receptor agonists mechanism of actions on glucose lowering and their connections with prolactin actions. Front Clin Diabetes Healthc. 4: 935872.
  4. Hsieh Y-T, Tu H-F, Yang M-H, Chen Y-F, Lan X-Y, Huang C-L, Chen H-M, Li W-C* (2021). Mitochondrial genome and its regulator TFAM modulates head and neck tumourigenesis through intracellular metabolic reprogramming and activation of oncogenic effectors. Cell Death & Disease, 12: 961.
  5. Chen S-G, Ugwu F, Li W-C, Caplice NM, Petcu EB, Yip SP, Huang CL* (2021). Vascular Tissue Engineering: Advanced Techniques and Gene Editing in Stem Cells for Graft Generation. Tissue Eng Part B Rev., 27:14-28.
  6. Lan X-Y, Chung T-T, Huang C-L, Lee Y-J, Li W-C*(2020). Traditional Herbal Medicine Mediated Regulations during Head and Neck Carcinogenesis. Biomolecules, 10: E1321.
  7. Yang H#, Wei Y-C#, Li W-C#, Chen H-Y, Lin H-Y, Chiang C-P, Chen H-M* (#: authors contributed equally) (2020). Natural Compounds Modulate Drug Transporter Mediated Oral Cancer Treatment. Biomolecules, 10:1335.
  8. Li W-C*, Huang C-H, Hsieh Y-T, Chen T-Y, Cheng L-H, Chen C-Y, Liu C-J, Chen H-M, Huang C-L, Lo J-F, Chang K-W (2020). Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis. Frontier in Oncology, 10:176.
  9. Hsieh Y-T, Chen Y-F, Lin S-C, Chang K-W, Li W-C* (2019). Targeting Cellular Metabolism Modulates Head and Neck Oncogenesis. Int J Mol Sci. 20: pii: E3960.
  10. Chen T-Y#, Hsieh Y-T#, Huang J-M#, Liu C-J, Chuang L-T, Huang P-C, Kuo T-Y, Chia H-Y, Chou C-Y, Chang C-W, Chen Y-F, Chen H-M, Lo J-F, Li W-C* (2019). Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumourigenesis. Neoplasia 21:641-652 (SCI) (#: authors contributed equally)
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