Jung-Chen Lin

<Education and Positions>

Graduate Institute of Immunology, College of Medicine, National Taiwan University (Ph.D, 2014 Jun.)

Immunology

Institute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University (M.S., 2004 Jun.)

Oral Immunology and Biology

<Discipline>

Immunoengineering, Biomimetic materials, Oral Immunology, Biochemistry

<Research focus>

Biomimetic biomaterials for immunoengineering and immune modulation

<Specialty>

Immunology, Bioengineering, Immunotherapy and Vaccinology

 <Publication List   (＃equal contribution)>

(Present - 2019)

(1) Hsu, C.Y., Tsai, P.C., Lin, J.C., Pai, C.H., Teng, Y.J., Yao, B.Y., Fei, C.Y., Shiau, G.H.M., Lin, L.C.W., Yang, H.C., Hu, C.M.J.*. 2025. Biomimetic Lymphocyte Capture by Polymer-Stabilized Superparamagnetic Antigen Presenting Cells Enriches Tumor-Reactive T cells and Improves Neoantigen Identification. Nat Commun 16 (1):5088 (IF=16.1; 8/134; Q1)

(2) Baghdasaryan, O.#, Khan, S.#, Lin, J.C.＃, Lee-Kin, J., Hsu, C.Y., Hu, C.M.J.* and Tan, C.* 2024. Synthetic control of living cells by intracellular polymerization. Trends Biotechnol 42(2):241-252. (IF=17.3; 3/158; Q1)

(3) Lin, C.L.; Fang, Z.S.; Hsu, C.Y.; Liu, Y.H.; Lin, J.C.; Yao, B.Y.; Li, F.A.; Yen, S.C.; Chang, Y.C., and Hu, C.M.J.* 2024.Rapid plasma membrane isolation via intracellular polymerization-mediated biomolecular confinement. Acta Biomater 173:325-335. (IF=9.7; 6/96; Q1)

(4) Chien, C.Y.＃, Lin, J.C.＃, Huang, C.Y., Hsu, C.Y., Yang, K.C., Chattopadhyay, S., Nikoloutsos, N, Hsieh, P.C., and Hu, C.M.J.* 2023. In situ hydrogelation of cellular monolayers enables conformal iobmembrane functionalization for xeno-free feeder Substrate engineering. Adv Healthc Mater e2201708. (IF=10; 8/96; Q1)

(5) Yang, K.C., Lin, J.C., Tsai, H.H., Hsu, C.Y., Shih, V, and Hu, C.M.J.* 2021. Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control. Drug Deliv Transl Res11(4):1420-1437. (IF=5.4; 43/136; Q2)

(6) Lin, J.C., Hsu, C.Y., Chen, J.Y., Fang, Z.S., Chen, H.W., Yao, B.Y., Shiau, G.H.M, Tsai, J.S., Gu, M., Jung, M.Y., Lee, T.Y., and Hu, C.M.J.* 2021. Facile transformation of murine and human primary dendritic cells into robust and modular artificial antigen-presenting systems by intracellular hydrogelation. Adv Mater 33 (30):2101190. (IF=29.4; 5/178; Q1)

(7) Chattopadhyay, S, Liu, Y.H., Fang, Z.S., Lin, C.L., Lin, J.C., Yao, B.Y., and Hu, C.M.J.* 2020. Synthetic immunogenic cell death mediated by intracellular delivery of STING agonist nanoshells enhances anticancer chemo-immunotherapy.Nano Lett 20:2246-2256. (IF=10.8; 21/178; Q1)

(8) Lin, L.C.W., Huang, C.Y., Yao, B.Y., Lin, J.C., Agrawal, A., Algaissi, A., Peng, B.H., Liu, Y.H., Huang, P.H., Juang, R.H., Chang, Y.C., Tseng, C.T., Chen, H.W., and Hu, C.M.J.* 2019. Viromimetic STING agonist-loaded hollow polymeric nanoparticles for safe and effective vaccination against middle east respiratory syndrome coronavirus. Advanced Functional Materials 29(28):1807616. (IF=19; 8/178; Q1)

(9) Lin, J.C.＃, Chien, C.Y.＃, Lin, C.L.＃, Yao, B.Y., Chen, Y.I., Liu, Y.H., Fang, Z.S., Chen, J.Y., Chen, W.Y., Lee, N.N., Chen, H.W., and Hu, C.M.J.* 2019. Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions. Nat Commun 10(1):1057. (IF=16.6; 6/73; Q1)

(2018 - 2006)

(10) Lin, L.C., Chattopadhyay, S, Lin J.C., and Hu, C.M.J.* 2018. Advances and opportunities in nanoparticle- and nanomaterial-based vaccines against bacterial infections. Adv Healthc Mater 7(13):e1701395. (IF=10; 8/96; Q1)

(11) Ka, S.M., Chao, L. K., Lin, J.C., Chen, S.T., Li, W.T., Lin, C.N., Cheng, J.C., Jheng, H.L., Chen A., and Hua, K.F.* 2016. A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways. Free Radic Biol Med 91:10-24. (IF=7.4 ;43/285; Q1)

(12) Chen, H.W., Huang, C.Y., Lin, S.Y., Fang, Z.S., Hsu, C.H., Lin, J.C., Chen, Y.I., Yao, B.Y., and Hu, C.M.J.* 2016.Synthetic virus-like particles prepared via protein corona formation enable effective vaccination in an avian model of coronavirus infection. Biomaterials 106:111-8. (IF=14; 4/96; Q1)

(13) Ka, S.M., Lin, J.C., Lin, T.J., Liu, F.C., Chao, L.K., Ho, C.L., Yeh, L.T., Sytwu ,H.K., Hua, K.F., Chen, A.* 2015. Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation. Arthritis Res Ther 17:331. (IF=4.9; 12/34; Q2)

(14) Lin, J.C., Lin, S.C., Chen, W.Y., Yen, Y.T., Lai, C.W., Tao, M.H., Lin, Y.L., Miaw. S.C., and Wu-Hsieh, B.A.* 2014.Dengue viral protease interaction with NF-kappaB inhibitor alpha/beta results in endothelial cell apoptosis and hemorrhage development. J Immunol 193:1258-67. (IF=4.4; 77/161; Q2)

(15) Chang, L.Y., Lin, J.C., Chang, C.W., Ho, W.H., Chen, Y.T., Peng, J.L., and Hung, S.L.* 2009. Inhibitory effects of safrole on phagocytosis, intracellular reactive oxygen species, and the activity of myeloperoxidase released by human polymorphonuclear leukocytes. J Periodontol 80:1330-7. (IF=4.3; 12/91; Q1)

(16) Chen, D.C., Lee, Y.Y., Yeh, P.Y., Lin, J.C., Chen, Y.L., and Hung, S.L.* 2008. Eugenol inhibited the antimicrobial functions of neutrophils. J Endod 34:176-80. (IF=4.2; 14/91; Q1)

(17) Lai, Y.L., Lin, J.C., Yang,S.F., Liu, T.Y., and Hung, S.L.* 2007. Areca nut extracts reduce the intracellular reactive oxygen species and release of myeloperoxidase by human polymorphonuclear leukocytes. J Periodontal Res 42:69-76. (IF=3.5; 26/91; Q2)

(18) Shui, H.A., Ka, S.M., Lin, J.C., Lee, J.H., Jin, J.S., Lin ,Y.F., Sheu, L.F., and Chen, A.* 2006. Fibronectin in blood invokes the development of focal segmental glomerulosclerosis in mouse model. Nephrol Dial Transplant 21:1794-802. (IF=6.1; 4/26; Q1)

<Grant Activity>

Individual Research Projects (as a Project Director/ Project Principal Investigator)

(1) Development of mechano-activation to enhance T cell function via modular rigidification of intracellularly polymerized dendritic cells (114-2320-B-A49-006-MY3, 2025.01-2027.12)

Individual Research Projects (as a Project Co-Principal Investigator)

(2) Dissecting the impact of facultative anaerobes and obligate anaerobes on oral epithelial cells and osteoblasts using intracellular hydrogel technology (114-2314-B-A49-027-MY2, 2025.08-2027.07)

(3) Targeting resistance-associated metabolic and molecular cues to facilitate chemo/radio therapeutic sensitivity in oral cancers  (114-2314-B-A49-026-, 2025.08-2026.07)

Editor, figure designer, and wrote mentoring plan (as a Postdoctoral Researcher)

(4) mRNA vaccine enhancement strategy via nanoparticle-mediated innate immunity coordination (2022.08-2024.7)

(5) Development and optimization of personalized nanoparticle anti-cancer vaccine (2019.08-2022.07)

(6) The development of adjuvant-loaded nanocarriers for influenza virus vaccines (2016.08-2019.10)

<Honors/ Awards>

2023 The 33th Wang Ming-Ning Medical and Pharmaceutical Research Award-Outstanding PhD Dissertation Award—awarded by Wang Ming-Ning Memorial Foundation

2023  Poster Outstanding Awards—awarded by The 6th International Symposium of Materials on Regenerative Medicine & Annual Meeting of Biomaterials and Control Released Society in Taiwan

2022 Post-doctoral Researcher Academic Research Award—awarded by Ministry of Science and Technology

2014 Post-graduate Excellent Research Award—awarded by College of Medicine, National Taiwan University.

<Patents>

Internally fixed lipid vesicle (I653990, Taiwan)    2019/03/21

Peptide-loaded carrier system and uses thereof (PCT/US2020/043963)    2021/02/04

Method for natural killer cell expansion (I784426, Taiwan)    2022/11/21

Artificial antigen presenting cell system and uses thereof (TW202208618A)

<Technology Transfer>

Artificial antigen presenting cell system and uses thereof (Celtec Inc.)    2020/08/21

<Conference Presentation>

1. Chung-Yao Hsu, Jung-Chen Lin, Gwo Harn Max Shiau, Bing-Yu Yao, Che-Ming Jack Hu (2023, Aug). Polymerized magnetic cells amenable to synapse formation enable selective capture of antigen-specific T lymphocytes. ISOMRM & BCRS Aug. 31 – Sep. 3 2023, Taipei, Taiwan 2023

2. Jung-Chen Lin, Chen-Ying Chien, Chi-Long Lin, Chung-Yao Hsu, Jui-Yi Chen, Bing-Yu Yao, Yu- Han Liu, Zih-Syun Fang, Hui-Wen Chen, Che-Ming J. Hu (2023, Aug). Gelated cells as a robust cell-mimicking biomaterial system for cancer immunotherapy and tissue engineering. ISOMRM & BCRS Aug. 31 – Sep. 3 2023, Taipei, Taiwan 2023

3. Chung-Yao Hsu, Jung-Chen Lin, Gwo Harn Max Shiau, Bing-Yu Yao, Che-Ming Jack Hu (2023, Jul). Polymerized magnetic cells amenable to synapse formation enable selective capture of antigen-specific T lymphocytes.

4. Gwo Harn M Shiau, Jeng Fong Chiou, Long-Sheng Lu, Shian Ying Sung, Yin-Ju Chen, Jung-Chen Lin, Chung-Yao Hsu, Che-Ming J. Hu (2023, Jul). Unbiased T cell expansion by cancer taxidermy. 

5. Chung-Yao Hsu, Lung-Chen Lin and Che-Ming Jack Hu (2022, Jul). Enabling antigen-specific T cell isolation via active cellular engagement with gelated cellular systems.

6. Chung-Yao Hsu, Lung-Chen Lin, Wei-Li Liao, Vicky Shih, Che-Ming Jack Hu (2020, Nov). Facile hydrogelation of dendritic cells for rigidity-dependent immune modulation.

7. Jung-Chen Lin, Chen-Ying Chien, Chi-Long Lin, Bing-Yu Yao, Yu-Han Liu, Zih-Syun Fang, Hui-Wen Chen and Che-Ming J. Hu (2019, Dec). Gelated dendritic cells as a robust artificial antigen presenting system for cancer immunotherapy . US-Japan Drug Delivery Symposium.

8. Jung-Chen Lin, Chen-Ying Chien, Chi-Long Lin, Bing-Yu Yao, Yu-Han Liu, Zih-Syun Fang, Hui-Wen Chen and Che-Ming J. Hu (2019, Mar). Preparation of Stable and Effective Artificial Antigen Presenting Cells by Intracellular Hydrogelation .

9. Jung-Chen Lin, Shih-Ching Lin, Wen-Yu Chen, Yu-Ting Yen Chin-Wen Lai, Mi-Hua Tao, Yi-Ling Lin, Shi-Chuen Miaw, Betty A. Wu-Hsieh (2015, May). Dengue Viral Protease Interaction with NF-kB Inhibitor a/b Results in Endothelial Cell Apoptosis and Hemorrhage Development.

<Invited Presentations>

2025.04.25 Gelating the Intracellular Cytosol: Unlocking Novel Strategies for Cancer Treatment and Tissue Engineering. Institute for Translational Research in  Biomedicine, Chang Gung Memorial Hospital

2024.10.15  Revolutionizing cancer therapy and tissue engineering: the hidden potential of polymerizing intracellular cytosol. Stomatology Department, Taipei Veterans General Hospital

2024.01.12 Polymerizing intracellular cytosol for novel applications in cancer therapy and tissue engineering. College of Dentistry, National Yang Ming Chiao Tung University

2023 Gelated cells (GCs) as a robust cell-mimicking biomaterial system for biomedicine: Present and future applications of GCs. Institute of Biology and Anatomy, National Defense Medical Center

2021 Instilling new life into cells with hydrogels: Present and future applications of gelated cells (GCs) in biomedicine. College of Dentistry, National Yang Ming Chiao Tung University

2019 Present and future applications of gelated cells (GCs) for biomedicine. Graduate Institute of Medical Sciences, National Defense Medical Center

<Contact>

Office: Dentistry Building, Room 313

Tel: 886-2-2826-7314

Email: linjungchen@nycu.com